Serology and Diagnostics
High Throughput Facility
University of Ottawa
Serology and Diagnostics
High Throughput Facility
University of Ottawa
OUR VISION
Provide population-scale molecular diagnostics and serology services for the surveillance of infectious diseases and studying vaccine immune responses in humans and animals.
OUR MISSION
Support research using cutting-edge high throughput robotic automation and provide research
study design and data analysis services.
Our Story
The Serology and Diagnostics High Throughput Facility opened its doors in January 2021 to support Canadian research efforts responding to the COVID-19 pandemic. Through large-cohort serological profiling of SARS-CoV-2 antibodies, we conducted sero-surveillance, assessed vaccine-dosing strategies, and provided valuable vaccine immune response information for for general and at-risk populations.
While COVID-19 research support is ongoing, we are actively incorporating our expertise into other pathogens of interest to bring Canada to the forefront of disease and pandemic management. We believe in the importance of proactive, One Health approaches to population health.
Our Pipeline
Study Design
Sample Receipt and Processing
Automated High Throughput Assays
Data Processing, Analysis and Archiving
Data Reporting and Publication Support
Impact Enhancements
Core Services
Hover over each step for more information
Contributions to epidemiology and infectious disease knowledge base
Call upon our scientific and operational expertise to assist in project development, logistical planning and grant writing. Our perspectives and experience conducting automated high throughput assays can provide an extra impact, and reduce unforeseen logistical complications, to bring your study to the next level.
-
Thorough sample receiving process to ensure samples arrive in good order
-
Documented plating and tracking of biosamples
-
In-house punching of dried blood spot samples with automatic plate map generation
-
Secure, short-term storage in dedicated 4° C, -20° C and -80° C space
-
Sample quality assessment and quality reporting
-
Detection of IgG, IgA, IgM against SARS-CoV-2 Spike and Nucleocapsid
-
Measurement of Spike antibody Neutralization capacity
-
Work with serum, plasma, dried Blood Spots
-
Throughput of over 12,000 samples/assays per week
-
Development of Influenza A and RSV antibody assays underway
-
Conversion of raw data to serological titers or antibody inhibitory capacity
-
Quality control of automated assay runs
-
Normalization of longitudinal data
-
Batch-to-batch normalization
Make robust conclusions and demonstrate data interpretation clearly with accurate and understandable visual representations. Our expertise can aid in manuscript preparation, including figure generation, contextualization of findings, methods descriptions, and manuscript editing.
Contributions to epidemiology and infectious disease knowledge base
Fact Sheet
ASSAY PERFORMANCE
Tracking of Assay variability
LONGITUDINAL DATA
Standards and controls for longitudinal data normalization
ENVIRONMENTAL TRACING
Humidity, Temperature, Reagent Lots, Aliquot Dates